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KMID : 0043320110340030369
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Archives of Pharmacal Research
2011 Volume.34 No. 3 p.369 ~ p.376
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Pulsatile multiparticulate drug delivery system for metoprolol succinate
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Jagdale Swati C.
Chede Sachin M.
Gulwady Ram
Kuchekar Bhanudas S.
Lokhande Pradeep D.
Shah Tejas P.
Chabukswar Anuruddha R.
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Abstract
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Cardiovascular diseases and their treatment pose a great challenge. Many instances of cardiovascular disease occur in the early morning hours. Hence, the objective of this study was to develop a time-controlled release formulation of metoprolol succinate based on a pulsatile multiparticulate (pellets) drug delivery system. The formulation was intended to be administered in the evening at 22:00 hours to evaluate symptoms of cardiovascular disease that are experienced in the early morning hours (from 04:00 to 06:00). Drug layering followed by a swelling layer and finally by an insoluble coat application was done using a Sanmour fluid bed processor. Metoprolol succinate layered on sugar pellets (74% w/w) layered with 20% (w/w) ion doshion resin P-547 and coated with 15% (w/w) ethocel with the addition of 20% castor oil showed a lag time of 4 h and was then followed a sigmoidal release pattern with more than 95% drug having been released by the 10th h.
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KEYWORD
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Pulsatile release, Ion doshion resin, Ethyl cellulose, Castor oil
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